2009
L'Oreal, Episkin, SkinEthic

PROMISING ALTERNATIVE METHOD FOR SKIN PENETRATION EVALUATION USING RECONSTRUCTED EPIDERMIS MODEL

Measurement of dermal bioavailability is necessary to evaluate the exposure andto estimate the risk associated with a cosmetic ingredient applied on the skin. Forsuch study, its use is time consuming and requires numerous replicates due to the variability ofthe donors.Reconstructed skin models have had a great development over the last tenyears. The Episkin(www.skinethic.com), highly reproducible, available in multi-wells, and directly usefulin its insert. It is an ex vivo human skin is the tool recommended by regulators. However,® model has the advantages to be commercially availablein vitro human epidermis equivalent model with histologicalprofile and metabolic capabilities similar to the human skin.