IN VITRO EPISKINTM SKIN CORROSION AS A REFERENCE TEST METHOD IN OECD TG431 FOR THE ASSESSMENT OF SKIN CORROSION IN SUB-CATEGORIES 1A, 1B AND 1C

Skin corrosion background1998: EpiSkinTM prospectively validated by ECVAM (ESAC statement on the test method)2000: Acceptance as EU Test Methods B.40 bis2004: EpiSkinTM adopted in OECD Test Guideline 431Currently: TG 431 under revision by the OECD-Inclusion of formal Performance Standards in an Annex of the TG- Inclusion of SkinEthicTM RHE- Inclusion of controls for interference with MTT assay- Inclusion of subcategorisation of corrosive chemicals according to UN GHS and EU CLP (Categories 1A, 1B, 1C)

In vitro test approach

AUTHORS : Alepee N. Cotovio J Grandidier M H

MODELS : EPISKIN

APPLICATIONS : Skin corrosion

2013 Society of Toxicology
L'Oreal