Scientific References

Development of a defined approach for eye irritation or serious eye damage for liquids

APPLICATIONS : Eye irritation

2019 Elsevier - Toxicology In vitro 57 (2019) 154-163 | L'Oréal Research & Innovation, Aulnay Sous Bois, France; Adriaens Consulting, Aalter, Belgium; Kao Corporation, Safety Science Research, Kanagawa, Japan; D. Bagley, Colgate-Palmolive Co., Piscataway, NJ, USA; Cosmetics Europe - The Personal Care Association, Brussels, Belgium; Chanel Parfums Beauté, Neuilly sur Seine, France; Henkel AG & Co. KGaA, Düsseldorf, Germany; Beiersdorf AG, Hamburg, Germany; Kao Corporation, S.A., Barcelona, Spain; HP Inc., Barcelona, Spain; VITO NV (Flemish Institute for Technological Research), Mol, Belgium l The Procter & Gamble Company, Egham, United Kingdom

AUTHORS : Adriaens E. Alepee N. McNamee P Pfannenbecker U

Development of a defined approach for eye irritation or serious eye damage for neat liquids

APPLICATIONS : Eye irritation OCULAR IRRITATION OF CHEMICAL

2019 Toxicology in Vitro | L'Oréal Research & Innovation, Aulnay Sous Bois, France b Adriaens Consulting, Aalter, Belgium c Kao Corporation, Safety Science Research, Kanagawa, Japan d Colgate-Palmolive Co., Piscataway, NJ, USA e Cosmetics Europe - The Personal Care Association, Brussels, Belgium f Chanel Parfums Beauté, Neuilly sur Seine, France g Henkel AG & Co. KGaA, Düsseldorf, Germany h Beiersdorf AG, Hamburg, Germany i Kao Corporation, S.A., Barcelona, Spain j HP Inc., Barcelona, Spain k VITO NV (Flemish Institute for Technological Research), Mol,

AUTHORS : Alepee N. Bouez C Cotovio J Dakic V De Vecchi R Garcia C Mattos G Oliveira V Rigaudeau A-S

Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

APPLICATIONS : PERCUTANEOUS ABSORPTION Permeability PHARMACOLOGY / TOXICOLOGY Skin corrosion Skin irritation SKIN IRRITATION OF CHEMICALS SKIN IRRITATION OF COSMETICS SKIN METABOLISM

2018 Vigil. sanit. debate 2018;6(1):64-71 | L'Oréal, EPISKIN

AUTHORS : Akita M Alepee N. Fujishiro M Hagino S Handa Y Ikeda H Imai N Jitsukawa S Katoh M Kurihara K Kyotani D Nomura S Ohno Y Okamoto Y Okumara H Omori T Sugibayashi K Sugiyama M Todo H Toyoda A

Comparative assessment of 24hr primary skin irritation test

APPLICATIONS : Skin irritation SKIN IRRITATION OF CHEMICALS SKIN IRRITATION OF COSMETICS

2018 Journal of Toxicological Sciences | NikoDerm Research Inc, Osaka ; Institut of Health Science, Shiga ; Kobe University School of Medecine, Kobe ; Josai University, Saitama ; Pola Chemical Industries, Yokohama ; Kihara Memorail Yokohama Foundation, Yokohama

AUTHORS : Alepee N. Cotovio J Grandidier MH Tornier C

An integrated testing strategy for in vitro skin corrosion and irritation assessment using SkinEthic™ Reconstructed Human Epidermis.

APPLICATIONS : Skin corrosion SKIN IRRITATION OF CHEMICALS SKIN IRRITATION OF COSMETICS

2015 Toxicology in Vitro 29 (2015) 1779–1792 | L'Oréal, Episkin

In vitro skin Corrosion and Irritation Assessment of Ingredients Using Episkin Model: Top-Down and Bottom-Up Approaches

MODELS : EPISKIN

APPLICATIONS : Skin corrosion SKIN IRRITATION OF CHEMICALS

2014 Society of Toxicology (SOT) Annual Meeting | L'Oréal, Research & Innovation

AUTHORS : Alepee N. Cotovio J Robert C Tornier C

The usefulness of the validated SkinEthic™ RHE test method to identify skin corrosive UN GHS subcategories.

APPLICATIONS : Skin corrosion

2014 Toxicology In Vitro, 2014, June; 28(4)-616-25 | SkinEthic, L'Oréal, Research & Innovation

Sub-categorisation of skin corrosive chemicals by the EpiSkin™ reconstructed human epidermis skin corrosion test method according to UN GHS: revision of OECD Test Guideline 431.

MODELS : EPISKIN

APPLICATIONS : Skin corrosion

2014 Toxicology In Vitro. 2014 Mar;28(2):131-45 | L'Oréal, Research & Innovation

In vitro skin corrosion and irritation assessment of ingredients using EpiSkin methods: Sequential Top-Down and Bottom-Up approaches

MODELS : EPISKIN

APPLICATIONS : Skin corrosion SKIN IRRITATION OF CHEMICALS SKIN IRRITATION OF COSMETICS

2014 L'Oreal (WC9) | L’Oréal Research & Innovation, France

AUTHORS : Alepee N. Cotovio J Tornier C

SkinEthic RHE method categorises chemicals between corrosive subcategories and non-corrosive as stated in OECD TG431

APPLICATIONS : Skin corrosion

2014 | Episkin, L'Oréal

Integrated approach for skin corrosion and skin irritation using in vitro SkinEthic RHE test methods

APPLICATIONS : Skin corrosion SKIN IRRITATION OF CHEMICALS SKIN IRRITATION OF COSMETICS

2014 | L'Oréal

AUTHORS : Alepee N. Cotovio J Grandidier M H

MODELS : EPISKIN

APPLICATIONS : Skin corrosion

IN VITRO EPISKINTM SKIN CORROSION AS A REFERENCE TEST METHOD IN OECD TG431 FOR THE ASSESSMENT OF SKIN CORROSION IN SUB-CATEGORIES 1A, 1B AND 1C

2013 Society of Toxicology | L'Oreal

AUTHORS : Alepee N. Bessou S. Cotovio J De Smedt A De Wever B Faller C Jones P A Le Varlet Béatrice Marrec-Fairley M McNamee P Pfannenbecker U Tailhardat M Van Goethem F

Cosmetics Europe Multi-Laboratory Pre-Validation of the SkinEthic™ Reconstituted Human Corneal Epithelium Test Method for the Prediction of Eye Irritation.

APPLICATIONS : OCULAR IRRITATION OF CHEMICAL

2013 Toxicology in vitro | L'Oreal

AUTHORS : Alepee N. Cotovio J Grandidier MH Gregoire S. Micheau Beatrice

MODELS : EPISKIN

APPLICATIONS : SKIN IRRITATION OF CHEMICALS

Influence of acidic extraction conditions on formazan assay: Assessment of test substances using in vitro EpiSkin skin irritation test method by HPLC and colorimetry

2013 Society of Toxicology (SOT) Annual Meeting | L'Oréal, Research & Innovation

In vitro EpiSkin skin corrosion as a reference test method in OECD TG431 for the assessment of skin corrosion in sub-categories 1A, 1B and 1C

MODELS : EPISKIN

APPLICATIONS : Skin corrosion

2013 Society of Toxicology (SOT) Annual Meeting | L'Oréal, Research & Innovation

AUTHORS : Alepee N. Cotovio J Tornier C

The Usefulness of the Validated SkinEthic RHE Method to Identify Skin Corrosive UN GHS Subcategories

APPLICATIONS : Skin corrosion

2013 Society of Toxicology (SOT) Annual Meeting | L'Oréal, Research & Innovation

AUTHORS : Alepee N. Cotovio J Grandidier MH Leblanc V. Robert C Seyler N. Tornier C

The In vitro SkinEthic RHE Skin Corrosion as a Reference Test Method in the Acute Testing Strategy

APPLICATIONS : Skin corrosion SKIN IRRITATION OF CHEMICALS

2013 Society of Toxicology (SOT) Annual Meeting | L'Oréal, Research & Innovation

AUTHORS : Alepee N. Bessou S. Boullay E. De Smedt A De Wever B Gregoire S. Jones P A Kunkel A. McNamee P Millet M. Pfannenbecker U Taalman R. Tailhardat M. Van Goethem F Wargniez W.